Computational Backbone Mutagenesis of Aβ Peptides: Probing the Role of Backbone Hydrogen Bonds in Aggregation
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چکیده
منابع مشابه
Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations.
One of the most frequent protein-protein interaction modules in mammalian cells is the postsynaptic density 95/discs large/zonula occludens 1 (PDZ) domain, involved in scaffolding and signaling and emerging as an important drug target for several diseases. Like many other protein-protein interactions, those of the PDZ domain family involve formation of intermolecular hydrogen bonds: C-termini o...
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15 صفحه اولDo all backbone polar groups in proteins form hydrogen bonds?
Evidence from proteins and peptides supports the conclusion that intrapeptide hydrogen bonds stabilize the folded form of proteins. Paradoxically, evidence from small molecules supports the opposite conclusion, that intrapeptide hydrogen bonds are less favorable than peptide-water hydrogen bonds. A related issue-often lost in this debate about comparing peptide-peptide to peptide- water hydroge...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2010
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp911533q